4-Fluorophenylacetyl chloride → HCID 67541782, compound

HRID 449375Notes

Reaction equation

HRID 449375 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](Cl)=[O:10])=[CH:4][CH:3]=1.Cl.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[C:24]([C:26]3[CH:35]=[C:34]4[C:29]([CH2:30][CH2:31][NH:32][CH2:33]4)=[CH:28][CH:27]=3)[N:23]=[C:22]([NH2:36])[N:21]=2)[CH2:16][CH2:15]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:32]2[CH2:31][CH2:30][C:29]3[C:34](=[CH:35][C:26]([C:24]4[CH:25]=[C:20]([N:17]5[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]5)[N:21]=[C:22]([NH2:36])[N:23]=4)=[CH:27][CH:28]=3)[CH2:33]2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 37449884-Fluorophenylacetyl chlorideHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 67541782HCID 67541782, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from (4-fluorophenyl)acetyl chloride (Aldrich, Cat. #466956) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=461.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3d36c34cb5d148c39a6bdad835615556
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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