HRID449382

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54340011

未命名化合物

结构：CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)OC3CCNCC3)CC4)nc(N)n2)CC1.Cl

HCID67541330

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(c2cc(-c3ccc4c(c3)CN(C(=O)OC3CCN(C(=O)OC5CCCC5)CC3)CC4)nc(N)n2)CC1

HCID49779589

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 4 starting from cyclopentyl 4-nitrophenyl carbonate and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=564.3.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f2dc5fd7405e498e961c0e99b86098a1
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08481732B2
来源说明: uspto-grants-2013_07

反应 SMILES

[C:1](=[O:18])(OC1C=CC([N+]([O-])=O)=CC=1)[O:2][CH:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl.[NH2:20][C:21]1[N:26]=[C:25]([C:27]2[CH:36]=[C:35]3[C:30]([CH2:31][CH2:32][N:33]([C:37]([O:39][CH:40]4[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]4)=[O:38])[CH2:34]3)=[CH:29][CH:28]=2)[CH:24]=[C:23]([N:46]2[CH2:51][CH2:50][N:49]([CH3:52])[CH2:48][CH2:47]2)[N:22]=1>>[NH2:20][C:21]1[N:26]=[C:25]([C:27]2[CH:36]=[C:35]3[C:30]([CH2:31][CH2:32][N:33]([C:37]([O:39][CH:40]4[CH2:45][CH2:44][N:43]([C:1]([O:2][CH:3]5[CH2:4][CH2:5][CH2:6][CH2:7]5)=[O:18])[CH2:42][CH2:41]4)=[O:38])[CH2:34]3)=[CH:29][CH:28]=2)[CH:24]=[C:23]([N:46]2[CH2:51][CH2:50][N:49]([CH3:52])[CH2:48][CH2:47]2)[N:22]=1