Cyclopentyl 4-nitrophenyl carbonate → 1-[(Cyclopentyloxy)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Cyclopentyl 4-nitrophenyl carbonate	HCID 54340011	—
Reactant	piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt	HCID 67541330	—
Product	1-[(Cyclopentyloxy)carbonyl]piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate	HCID 49779589	—

Reaction Steps

This compound was prepared by using procedures analogous to those described for the synthesis of Example 67, Step 4 starting from cyclopentyl 4-nitrophenyl carbonate and piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate HCl salt. Analytic LCMS (M+H)+: m/z=564.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08481732B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-f2dc5fd7405e498e961c0e99b86098a1
Source note	uspto-grants-2013_07