Hydrochloric Acid → HCID 67541748, compound

HRID 449385Notes

Reaction equation

HRID 449385 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15]([C:19](=[O:34])[CH2:20][CH:21]4[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[C:5]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:4]=1>O1CCOCC1.CO>[CH3:41][N:38]1[CH2:37][CH2:36][N:35]([C:5]2[CH:6]=[C:7]([C:9]3[CH:18]=[C:17]4[C:12]([CH2:13][CH2:14][N:15]([C:19](=[O:34])[CH2:20][CH:21]5[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]5)[CH2:16]4)=[CH:11][CH:10]=3)[N:8]=[C:3]([NH2:2])[N:4]=2)[CH2:40][CH2:39]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67542180HCID 67542180, compound

Product 1

HCID 67541748HCID 67541748, compoundYield 123.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2 mL of 4.0 N HCl in 1,4-dioxane was added to a solution of tert-butyl 4-{2-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}piperidine-1-carboxylate (25 mg, 0.045 mmol) in methanol (1.0 mL). The reaction mixture was stirred at r.t. for 2 h. The volatiles were removed under reduced pressure to afford the product as an HCl salt (25 mg, 98%). Analytic LCMS (M+H)+: m/z=450.2.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-6db7c175a7fc4456b3b1d1f7680530be
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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