Cyclopropanecarbonyl chloride → HCID 67542247, compound

HRID 449386Notes

Reaction equation

HRID 449386 reaction equation
[CH:1]1([C:4](Cl)=[O:5])[CH2:3][CH2:2]1.Cl.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[C:19]([C:21]3[CH:30]=[C:29]4[C:24]([CH2:25][CH2:26][N:27]([C:31](=[O:39])[CH2:32][CH:33]5[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]5)[CH2:28]4)=[CH:23][CH:22]=3)[N:18]=[C:17]([NH2:40])[N:16]=2)[CH2:11][CH2:10]1>>[CH:1]1([C:4]([N:36]2[CH2:35][CH2:34][CH:33]([CH2:32][C:31]([N:27]3[CH2:26][CH2:25][C:24]4[C:29](=[CH:30][C:21]([C:19]5[CH:20]=[C:15]([N:12]6[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]6)[N:16]=[C:17]([NH2:40])[N:18]=5)=[CH:22][CH:23]=4)[CH2:28]3)=[O:39])[CH2:38][CH2:37]2)=[O:5])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 67541747HCID 67541747, compound

Product 1

HCID 67542247HCID 67542247, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 71, Step 4 starting from cyclopropanecarbonyl chloride (Aldrich, Cat. #C116807) and 4-(4-methylpiperazin-1-yl)-6-[2-(piperidin-4-ylacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=518.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2250230d327840cf95cfc01659ce7760
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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