反应详情

A solution of 4-(2-bromo-1,3-thiazol-5-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo-[2,3-d]pyrimidine (370 mg, 0.90 mmol) in DCM (5.0 mL) and TFA (1.0 mL) was stirred at room temperature for 7 hours. The mixture was then concentrated, re-dissolved in methanol (2 mL), and ethylenediamine (0.5 mL) was added. The mixture was stirred for 6 hours at room temperature. The mixture was diluted with DCM (10 mL), and the precipitate was isolated by filtration and washed with a small amount of DCM to afford desired product (182 mg, 72%).

1. concentrationThe mixture was then concentrated
2. dissolutionre-dissolved in methanol (2 mL)
3. additionethylenediamine (0.5 mL) was added
4. additionThe mixture was diluted with DCM (10 mL)
5. customthe precipitate was isolated by filtration
6. washwashed with a small amount of DCM