Hydrochloric Acid → Hydrochloric Acid

HRID 449396Notes

Reaction equation

HRID 449396 reaction equation
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][C:10]=2[CH3:26])[CH:6]=[C:5]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)[N:4]=1>O1CCOCC1.CO>[ClH:1].[CH3:26][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:9]=1[C:7]1[CH:6]=[C:5]([N:27]3[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]3)[N:4]=[C:3]([NH2:2])[N:8]=1)[CH2:16][NH:15][CH2:14][CH2:13]2.[ClH:1]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 59496585HCID 59496585, compound

Product 2

HCID 313Hydrochloric AcidHCID 67541974HCID 67541974, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2.0 mL of 4 N HCl in 1,4-dioxane was added to a solution of tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-6-methyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.19 g, 0.43 mmol) in methanol (1 mL). The reaction mixture was stirred at r.t. for 30 min The volatiles were removed under reduced pressure to afford the desired product as an HCl salt. Analytic LCMS (M+H)+: m/z=339.2.

Workup

  1. customwere removed under reduced pressure

Sources & evidence

ORD record
ord-e6f0d6a677f0410da9c6f4d30d87cf70
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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