Phosgene → HCID 59496724, compound

HRID 449402Notes

Reaction equation

HRID 449402 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:9](Cl)(Cl)=[O:10].Cl.[CH3:14][N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[C:25]([C:27]3[CH:36]=[C:35]4[C:30]([CH2:31][CH2:32][NH:33][CH2:34]4)=[CH:29][CH:28]=3)[N:24]=[C:23]([NH2:37])[N:22]=2)[CH2:17][CH2:16]1>>[NH2:37][C:23]1[N:24]=[C:25]([C:27]2[CH:36]=[C:35]3[C:30]([CH2:31][CH2:32][N:33]([C:9]([N:2]([CH:3]4[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]4)[CH3:1])=[O:10])[CH2:34]3)=[CH:29][CH:28]=2)[CH:26]=[C:21]([N:18]2[CH2:17][CH2:16][N:15]([CH3:14])[CH2:20][CH2:19]2)[N:22]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 7514N-MethylcyclohexylamineHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 59496724HCID 59496724, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from N-methylcyclohexanamine (Aldrich, Cat. #103322), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=464.5.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-826e1fa598804e3db49b883cadbaf9c6
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

Loading…