Phosgene → HCID 49779701, compound

HRID 449409Notes

Reaction equation

HRID 449409 reaction equation
[C:1](Cl)(Cl)=[O:2].Cl.[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([C:19]3[CH:28]=[C:27]4[C:22]([CH2:23][CH2:24][NH:25][CH2:26]4)=[CH:21][CH:20]=3)[N:16]=[C:15]([NH2:29])[N:14]=2)[CH2:9][CH2:8]1.[NH2:30][C@@H:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH2:33][C@@H:32]1[OH:40]>>[NH2:29][C:15]1[N:16]=[C:17]([C:19]2[CH:28]=[C:27]3[C:22]([CH2:23][CH2:24][N:25]([C:1]([NH:30][C@@H:31]4[C:39]5[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=5)[CH2:33][C@@H:32]4[OH:40])=[O:2])[CH2:26]3)=[CH:21][CH:20]=2)[CH:18]=[C:13]([N:10]2[CH2:9][CH2:8][N:7]([CH3:6])[CH2:12][CH2:11]2)[N:14]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779701HCID 49779701, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 42 starting from phosgene, 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt and (1R,2S)-1-aminoindan-2-ol. Analytic LCMS (M+H)+: m/z=500.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a5e73383bf8e4e86a2d14860a7528c32
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

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