Lithium hydroxide, monohydrate → 2-Cyclohexylpropionic acid

Temperature

60 °C

A reaction mixture of methyl 2-cyclohexylpropanoate (0.30 g, 1.8 mmol) and lithium hydroxide monohydrate (0.12 g, 2.8 mmol) in methanol (3.0 mL) and water (1.0 mL) was stirred at 60° C. for 2 h. The mixture was concentrated to remove methanol, washed with ether to remove some impurity, then adjusted to pH=2 with 1 N HCl (aqueous). The mixture was extracted with ethyl acetate (3×20 mL). The combined organic layers were dried over MgSO4, filtered and concentrated to afford the crude product which was directly used for next step without further purification.

1. concentrationThe mixture was concentrated
2. customto remove methanol
3. washwashed with ether
4. customto remove some impurity
5. extractionThe mixture was extracted with ethyl acetate (3×20 mL)
6. dry with materialThe combined organic layers were dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated

ORD record

ord-7261de6015e34e7c8be81f05839b39a1

Source dataset

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08481732B2