1-Isocyanato-1-(trifluoromethyl)cyclopropane → HCID 49779903, compound

HRID 449445Notes

Reaction equation

HRID 449445 reaction equation
[N:1]([C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][CH2:5]1)=[C:2]=[O:3].Cl.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[C:23]([C:25]3[CH:34]=[C:33]4[C:28]([CH2:29][CH2:30][NH:31][CH2:32]4)=[CH:27][CH:26]=3)[N:22]=[C:21]([NH2:35])[N:20]=2)[CH2:15][CH2:14]1>>[NH2:35][C:21]1[N:22]=[C:23]([C:25]2[CH:34]=[C:33]3[C:28]([CH2:29][CH2:30][N:31]([C:2]([NH:1][C:4]4([C:7]([F:10])([F:9])[F:8])[CH2:6][CH2:5]4)=[O:3])[CH2:32]3)=[CH:27][CH:26]=2)[CH:24]=[C:19]([N:16]2[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]2)[N:20]=1

Participants

3

Reactant 2

HCID 589208171-Isocyanato-1-(trifluoromethyl)cyclopropaneHCID 675414894-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

Product 1

HCID 49779903HCID 49779903, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from 1-isocyanato-1-(trifluoromethyl)cyclopropane, and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=476.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c50a74b7f0f54b0489e744f6d0ea6359
Source dataset
uspto-grants-2013_07
Patent number
US08481732B2

Reaction notes

Loading…