反应详情

tert-Butyl 3-(3-(3-cyanophenoxy)phenyl)-1-(dimethylamino)-1-oxopropan-2-ylcarbamate (0.045 g crude) was taken up in 4 M HCl in dioxane 2 ml and stirred at r.t. for 2 h. The reaction was complete, concentrated under reduced pressure in vacuo. The residue was taken up in acetonitrile and reconcentrated under reduced pressure two times to give crude 2-amino-3-[3-(3-cyanophenoxy)phenyl]-N,N-dimethylpropanamide-HCl salt (0.045 g) as a semisolid residue which was directly used in next step reaction without further purification. Analytical LCMS (M+H)+: m/z=310.0

1. concentrationconcentrated under reduced pressure in vacuo