反应详情

The tert-butyl{1-[3-(4-chloro-2-cyanophenoxy)phenyl]ethyl}carbamate (0.040 g) was taken up in 4 M HCl in dioxane (3 mL) at r.t. and was stirred for 2 h. The reaction was concentrated under reduced pressure, taken up in acetonitrile and re-concentrated under reduced pressure two times to give crude 2-[3-(1-aminoethyl)phenoxy]-5-chlorobenzonitrile as HCl salt (0.045 g) as a semisolid residue. Analytical LCMS (M+H)+: m/z=272.9.

1. concentrationThe reaction was concentrated under reduced pressure
2. concentrationre-concentrated under reduced pressure two times