反应详情

温度

150 °C

In a 15 mL microwave tube was dissolved tert-butyl 5-((cyclobutylamino)methyl)pyrazin-2-ylcarbamate (330 mg, 1.19 mmol, Eq: 1.00) in 2,2,2-trifluoroethanol (119 mg, 12 ml, 1.19 mmol, Eq: 1.00) and the resulting mixture was heated in seal tube at 150° C. for 3 hrs. The crude reaction mixture was concentrated in vacuo, treated with MeOH and re-concentrated to remove residual trifluoroethanol. The material was azeotroped with toluene to afford 200 mg (95%) of the title compound.

1. customThe crude reaction mixture
2. concentrationwas concentrated in vacuo
3. additiontreated with MeOH
4. concentrationre-concentrated
5. customto remove residual trifluoroethanol
6. customThe material was azeotroped with toluene