反应详情

3-Methylpicolinic acid (10 g, 72.9 mmol) in EtOH (80 mL) and water (80 mL) was treated with PtO2 (4 g) and placed under a H2 atmosphere (60 psi). The mixture was shaken vigorously for 18 h, and then the PtO2 was degassed via vacuum for 30 min. The mixture was filtered through a Celite pad, which was washed with EtOH (3 50 mL) and H2O (3 80 mL). The solution was concentrated to afford (+/−) cis-3-methylpiperidine-2-carboxylic acid, which was used without further purification.

1. customthe PtO2 was degassed via vacuum for 30 min
2. filtrationThe mixture was filtered through a Celite pad, which
3. washwas washed with EtOH (3 50 mL) and H2O (3 80 mL)
4. concentrationThe solution was concentrated