反应详情

温度

130 °C

0.27 g (II) are placed in 3 ml dioxane, then 0.45 ml diisopropylethylamine are added followed by 0.25 g (S)-5-amino-1-methylpiperidin-2-one. The reaction mixture is heated to 130° C. until there is no further reaction, and after cooling evaporated down. The product is extracted with dichloromethane and purified by chromatography (preparative HPLC, method A). 0.26 g (III-2) are obtained as a solid. Analytical HPLC-MS (method A): RT=1.06 min.

1. customno further reaction
2. temperatureafter cooling
3. customevaporated down
4. extractionThe product is extracted with dichloromethane
5. custompurified by chromatography (preparative HPLC, method A)
6. custom0.26 g (III-2) are obtained as a solid