反应详情

温度

160 °C

1.4 g (II) are placed in 10 ml dioxane, then 3.6 ml diisopropylethylamine followed by 1 g of 1-aminocyclopropanemethanol (see 4.2) are added. The reaction mixture is heated at 160° C. until there is no further reaction, and after cooling evaporated down. The residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath and the solid is suction filtered and dried. 1.24 g (III-4) are obtained as a solid.

1. additionare added
2. customno further reaction
3. temperatureafter cooling
4. customevaporated down
5. additionThe residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath
6. filtrationfiltered
7. customdried
8. custom1.24 g (III-4) are obtained as a solid