反应详情

温度

150 °C

To the solution of 2,6-dichloro-4-iodo-N-(pyridin-4-yl)benzamide (0.15 g, 0.38 mmol) in DMF (2 mL) was added CuCN (0.17 g, 1.9 mmol). The mixture was heated at 150° C. under the irradiation of microwave for 1 hour. After the completion of the reaction, the mixture was filtered through Celite and purified by acid HPLC(YMC, 150 mm×30 mm, gradient: CH3CN/0.5% TFA, 10-50, 17 min) to afford the desired product (25.4 mg, yield: 23%). 1HNMR (DMSO-d6, 400 MHz): 611.95 (s, 1H), 8.74 (br, 2H), 8.33 (s, 2H), 7.97 (2H). LCMS (ESI) m/z: 292.1 [M+H+]

1. customAfter the completion of the reaction
2. filtrationthe mixture was filtered through Celite
3. custompurified by acid HPLC(YMC, 150 mm×30 mm, gradient