2,4,6-Trichlorobenzoic acid → 2,4,6-Trichlorobenzoyl chloride

HRID 449912Notes

Reaction equation

HRID 449912 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7]([Cl:12])[C:3]=1[C:4](O)=[O:5].O=S(Cl)[Cl:15]>>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7]([Cl:12])[C:3]=1[C:4]([Cl:15])=[O:5]

Participants

3

Reactant 2

HCID 57642,4,6-Trichlorobenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 27337032,4,6-Trichlorobenzoyl chlorideYield 93%

Procedure

A solution of 2,4,6-trichlorobenzoic acid (1.0 g, 4.0 mmol) in SOCl2 (5 mL) was heated to reflux for 30 min under nitrogen atmosphere. The reaction was concentrated under reduced pressure to give 2,4,6-trichlorobenzoyl chloride (900 mg, 93% yield), which was used in the next step without further purification.

Workup

  1. temperatureto reflux for 30 min under nitrogen atmosphere
  2. concentrationThe reaction was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7eb410a5d5fb4b238309274731011037
Source dataset
uspto-grants-2013_07
Patent number
US08486950B2

Reaction notes

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