反应详情

温度

0 °C

Ethyl 2-diazo-3-(2-fluorophenyl)-3-oxopropanoate (1.06 g, 4.49 mmol) was dissolved in acetonitrile (20 mL), cooled to 0° C. and treated with tri-n-butylphosphine (1.16 mL, 4.71 mmol, 1.05 equiv). The mixture was warmed to ambient temperature and after 10 minutes, was concentrated in vacuo. The residue was purified via silica gel gradient chromatography (100:0 to 75:25; hexanes:ethyl acetate) to provide the titled compound.

1. temperatureThe mixture was warmed to ambient temperature and after 10 minutes
2. concentrationwas concentrated in vacuo
3. customThe residue was purified via silica gel gradient chromatography (100:0 to 75:25; hexanes:ethyl acetate)