反应详情

2-Picoline (10.0 g, 0.1 mol) was added to a solution of alpha-bromoacetophenone (21.4 g, 0.1 mol) in methanol (150 ml). The solution was heated to reflux for 1 hr. The solvent was evaporated under vacuum to yield a solid, which was recrystallised from ethyl acetate/methanol. The resulting white solid was dried under vacuum to give 2-methyl-1-(2-oxo-2-phenyl-ethyl)-pyridinium bromide (18.0 g, 86%).

1. temperatureThe solution was heated
2. temperatureto reflux for 1 hr
3. customThe solvent was evaporated under vacuum
4. customto yield a solid, which
5. customwas recrystallised from ethyl acetate/methanol
6. customThe resulting white solid was dried under vacuum