反应详情

To a solution of 3-thiophene carboxylic acid (2.0 g, 15.60 mmol) in methanol (30 ml) was added a catalytic amount of sulphuric acid (0.5 ml) and the reaction mixture was heated to reflux for 2 hr. The solvent was removed under reduced pressure and the residue was poured into ice-cold water and extracted with ethyl acetate. The organic layer was washed with water, concentrated and dried to give 3-thiophene carboxylic acid methyl ester (1.8 g, 81%).

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 2 hr
3. customThe solvent was removed under reduced pressure
4. additionthe residue was poured into ice-cold water
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with water
7. concentrationconcentrated
8. customdried