反应详情

To an ice-cold solution of 4-amino-benzoyl chloride (0.38 g, 2.45 mmol) in tetrahydrofuran (2 ml) was added aqueous ammonia solution (15 ml). The reaction mixture was stirred at room temperature for 12 hr. The solvent was removed under vacuum, water added and the compound was extracted into ethyl acetate. The organic layer was dried and concentrated under vacuum. The crude compound was purified using silica gel column chromatography, using chloroform/methanol as eluent, to yield 4-amino-benzamide (0.1 g, 30%).

1. customThe solvent was removed under vacuum, water
2. additionadded
3. extractionthe compound was extracted into ethyl acetate
4. customThe organic layer was dried
5. concentrationconcentrated under vacuum
6. customThe crude compound was purified