反应详情

温度

90 °C

Powdered sodium hydroxide (1 g, 28.77 mmol) was added to a solution of 3-nitro phenol (2 g, 14.35 mmol) in DMF (15 ml) and cooled in an ice-bath. Ethyl bromoacetate (3.2 ml, 28.77 mmol) was added, and the reaction mixture was heated at 90° C. for 7 hr. The reaction mixture was cooled and quenched with ice water. The product was extracted with ethyl acetate, washed with water and dried. Concentration under reduced pressure gave (3-nitrophenoxy)-acetic acid ethyl ester (2.2 g, 68%) as oil.

1. temperaturecooled in an ice-bath
2. temperatureThe reaction mixture was cooled
3. customquenched with ice water
4. extractionThe product was extracted with ethyl acetate
5. washwashed with water
6. customdried
7. concentrationConcentration under reduced pressure