反应详情

4-nitro acetophenone (3 g, 18.18 mmol), ethylene glycol (1.35 g, 21.81 mmol) and p-toluene sulfonic acid (0.62 g) were taken in toluene and heated to reflux using a Dean-Stark water separator, until no more water was collected. The reaction mixture was cooled, water was added and the toluene layer separated. The aqueous layer was washed again with toluene and the toluene washings combined, dried and evaporated under reduced pressure to give 2-methyl-2-(4-nitro-phenyl)-[1,3]dioxolane (2.7 g, 71%) as oil.

1. temperatureheated
2. temperatureto reflux
3. customwas collected
4. temperatureThe reaction mixture was cooled
5. additionwater was added
6. customthe toluene layer separated
7. washThe aqueous layer was washed again with toluene
8. customdried
9. customevaporated under reduced pressure