HCID 62005685, compound → HCID 53402843, compound

HRID 450071Notes

Reaction equation

HRID 450071 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH2:7][N:6]1[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH2:7][N:6]1[C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=1)=[O:4]

Participants

4

Reactant 1

HCID 62005685HCID 62005685, compound

Product 1

HCID 53402843HCID 53402843, compoundYield 72.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(4-nitro-phenyl)-pyrrolidine-2-carboxylic acid methyl ester (0.55 g, 2.2 mmol) in methanol (15 ml) was hydrogenated over 10% Pd—C (50 mg) at 30 psi until no further gas uptake was observed. The reaction mixture was then filtered over celite and the filtrate evaporated to yield 1-(4-amino-phenyl)-pyrrolidine-2-carboxylic acid methyl ester (0.35 g, 72%).

Workup

  1. filtrationThe reaction mixture was then filtered over celite
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-f56950bbdb1b484bb050eecc3fc93d8d
Source dataset
uspto-grants-2013_07
Patent number
US08486962B2

Reaction notes

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