反应详情

温度

55 °C

Iron powder (1.3 g, 23.2 mol) was added to a solution of 1-nitro-4-(2,2,3,3-tetrafluoro-propoxy)-benzene (600 mg, 2.4 mmol) in acetic acid (4 ml) and heated at 50-60° C. for 1 hr. The reaction mixture was filtered hot over celite and washed with ethyl acetate. The filtrate was washed with water, 5% sodium hydroxide solution, brine and then dried over anhydrous sodium sulfate. The filtrate was evaporated to dryness to yield 4-(2,2,3,3-tetrafluoro-propoxy)-phenylamine (300 mg, 56.7%) as solid.

1. filtrationThe reaction mixture was filtered hot over celite
2. washwashed with ethyl acetate
3. washThe filtrate was washed with water, 5% sodium hydroxide solution, brine
4. dry with materialdried over anhydrous sodium sulfate
5. customThe filtrate was evaporated to dryness