反应详情

A mixture of 3-(4-nitrophenyl)-pentane-2,4-dione (50 mg, 0.22 mmol), hydroxylamine hydrochloride (15 mg, 0.22 mmol) and pyridine (17 mg, 0.22 mmol) in ethanol (10 ml) was heated to reflux overnight. Evaporation of the solvent gave a residue which was partitioned between water and ethyl acetate. The organic layer was separated, washed with water, then brine and dried. Evaporation to dryness yielded 3,5-dimethyl-4-(4-nitrophenyl)-isoxazole (44 mg, 90%) as solid.

1. temperaturewas heated
2. temperatureto reflux overnight
3. customEvaporation of the solvent
4. customgave a residue which
5. customwas partitioned between water and ethyl acetate
6. customThe organic layer was separated
7. washwashed with water
8. dry with materialbrine and dried
9. customEvaporation to dryness