反应详情

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) is stirred in 6 M aq. HCl-solution (120 mL) and AcOH (250 mL) at reflux for 24 h. The reaction mixture is cooled, concentrated, diluted with water and concentrated again. The residue is diluted with water, stirred under cooling and filtered. The filtercake is washed and dried to give the sub-title compound.

1. temperatureThe reaction mixture is cooled
2. concentrationconcentrated
3. additiondiluted with water
4. concentrationconcentrated again
5. additionThe residue is diluted with water
6. temperatureunder cooling
7. filtrationfiltered
8. washThe filtercake is washed
9. customdried