HCID 178482395, compound → HCID 178482394, compound

HRID 450335Notes

Reaction equation

HRID 450335 reaction equation
[F:1][C:2]([F:34])([F:33])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:27][CH2:26][CH:25]([C:28]([F:31])([F:30])[F:29])[CH2:24][CH2:23]2)[CH2:5][CH2:4]1>[Ni].C1COCC1>[F:34][C:2]([F:1])([F:33])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:23][CH2:24][CH:25]([C:28]([F:30])([F:31])[F:29])[CH2:26][CH2:27]2)[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 178482395HCID 178482395, compound

Product 1

HCID 178482394HCID 178482394, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide (120 mg, 0.24 mmol), Ra—Ni (30 mg) and THF (20 mL) is stirred under 50 psi H2-atmosphere for 4 h. The mixture is filtered, and the filtrate is concentrated.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-6f835e3c2c86494ba89bdd9cc72f495c
Source dataset
uspto-grants-2013_07
Patent number
US08486968B2

Reaction notes

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