HCID 178482397, compound → HCID 178482396, compound

Participants

Reaction Steps

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-fluoro-piperidinyl)-nicotinic acid amide (100 mg, 0.22 mmol), Pd/C (50 mg) and THF (15 mL) is stirred under 50 psi H2-atmosphere for 3 h. The mixture is filtered, and the filtrate is concentrated. HPLC Rt=1.28 min (method B). MS m/z: 418 [M+H]+.

Provenance & Evidence