HCID 178482397, compound → HCID 178482396, compound

HRID 450337Notes

Reaction equation

HRID 450337 reaction equation
[F:1][C:2]([F:31])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:27][CH2:26][CH:25]([F:28])[CH2:24][CH2:23]2)[CH2:5][CH2:4]1>[Pd].C1COCC1>[F:31][C:2]([F:1])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[N:13][C:12]=2[N:22]2[CH2:27][CH2:26][CH:25]([F:28])[CH2:24][CH2:23]2)[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 178482397HCID 178482397, compound

Product 1

HCID 178482396HCID 178482396, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-fluoro-piperidinyl)-nicotinic acid amide (100 mg, 0.22 mmol), Pd/C (50 mg) and THF (15 mL) is stirred under 50 psi H2-atmosphere for 3 h. The mixture is filtered, and the filtrate is concentrated. HPLC Rt=1.28 min (method B). MS m/z: 418 [M+H]+.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-9c3d85120a7b4e2b98bc5c31953d7a5f
Source dataset
uspto-grants-2013_07
Patent number
US08486968B2

Reaction notes

Loading…