HCID 178508580, compound → HCID 178507777, compound

HRID 450339Notes

Reaction equation

HRID 450339 reaction equation
[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH2:20])=[N:13][C:12]=2[N:21]2[CH2:26][CH2:25][CH:24]([F:27])[CH2:23][CH2:22]2)[CH2:5][CH2:4]1>[Pd].C1COCC1>[F:30][C:2]([F:1])([F:29])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:20])=[N:13][C:12]=2[N:21]2[CH2:26][CH2:25][CH:24]([F:27])[CH2:23][CH2:22]2)[CH2:7][CH2:8]1

Participants

4

Reactant 1

HCID 178508580HCID 178508580, compound

Product 1

HCID 178507777HCID 178507777, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The subtitle compound is prepared in analogy to 2c from N-(trans-4-trifluoromethyl-cyclohexyl)-6-amino-5-nitro-2-(4-fluoro-piperidinyl)-nicotinic acid amide, Pd/C (50 mg) and THF (15 mL) under 50 psi H2-atmosphere.

Sources & evidence

ORD record
ord-d6254fc4c71c4977895157c581728600
Source dataset
uspto-grants-2013_07
Patent number
US08486968B2

Reaction notes

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