Triethylamine → HCID 178458615, compound

HRID 450378Notes

Reaction equation

HRID 450378 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH:12]([O:15][C:16]1[NH:20][N:19]=[C:18]([NH2:21])[CH:17]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:21][C:18]2[CH:17]=[C:16]([O:15][CH:12]([CH3:14])[CH3:13])[NH:20][N:19]=2)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 5212662,4-Dichloro-5-nitropyrimidineHCID 1784587215-Isopropoxy-1H-pyrazol-3-amine2×

Product 1

HCID 178458615HCID 178458615, compoundYield 32.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2,4-dichloro-5-nitropyrimidine (2 g) and 5-isopropoxy-1H-pyrazol-3-amine (Intermediate 6, 1.5 g) in acetonitrile (50 mL) with triethylamine (5 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (Hexane/Ethyl acetate) to afford 1 g of the title compound. MS (electrospray): 299 (M+1) for C10H12ClN6O3.

Workup

  1. concentrationThe resulting mixture was concentrated
  2. customthe resulting residue was separated by silica gel column (Hexane/Ethyl acetate)

Sources & evidence

ORD record
ord-a4518c56af2344f0bdbf027c98ab473e
Source dataset
uspto-grants-2013_07
Patent number
US08486966B2

Reaction notes

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