HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoropyridine-2-carboxaldehyde → (S)-N-[(5-Fluoropyridin-2-yl)methylene]-2-methylpropane-2-sulfinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoropyridine-2-carboxaldehyde | HCID 10351697 | — |
| Reactant | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| Reactant | (R,E)-N-(2-((tert-butyldimethylsilyl)oxy)ethylidene)-2-methylpropane-2-sulfinamide | HCID 86644143 | — |
| Product | (S)-N-[(5-Fluoropyridin-2-yl)methylene]-2-methylpropane-2-sulfinamide | HCID 68781418 | — |
Reaction Steps
The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 21, using 5-fluoropyridine-2-carbaldehyde and (S)-2-methylpropane-2-sulfinamide as the starting materials. 1H NMR (300 MHz, CDCl3) δ ppm 8.67 (s, 1H) 8.58 (s, 1H) 8.06 (dd, J=8.29, 4.52 Hz, 1H) 7.51 (t, J=7.91 Hz, 1H) 1.20-1.33 (m, 9H). The product was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486966B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-99a4d028f36e46bbbbdb985736756c2b |
| Source note | uspto-grants-2013_07 |