反应详情

10 g of tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate, 4.42 g of 3,3,3-trifluoropropionaldehyde, 17.61 g of sodium triacetoxyborohydride and 4.51 ml of acetic acid are added, at AT, to 250 ml of DCM, and then the mixture is stirred for 3 hours. Water is added and the expected compound is extracted with DCM, and the organic phase is washed with a saturated solution of NaHCO3 and then with water. After drying of the organic phase, filtration and evaporation to dryness, 13 g of expected compound are obtained.

1. extractionthe expected compound is extracted with DCM
2. washthe organic phase is washed with a saturated solution of NaHCO3
3. dry with materialAfter drying of the organic phase, filtration and evaporation to dryness, 13 g of expected compound
4. customare obtained