Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

HRID 450546Notes

Reaction equation

HRID 450546 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([O:9][CH:10]([CH3:12])[CH3:11])[CH:3]=1.Cl[C:14]1[C:15]2[C:22]([CH3:23])=[C:21]([C:24]([O:26][CH3:27])=[O:25])[S:20][C:16]=2[N:17]=[CH:18][N:19]=1>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:14]2[C:15]3[C:22]([CH3:23])=[C:21]([C:24]([O:26][CH3:27])=[O:25])[S:20][C:16]=3[N:17]=[CH:18][N:19]=2)=[C:4]([O:9][CH:10]([CH3:12])[CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 37563854-Fluoro-2-(1-methylethoxy)benzenamine

Product 1

HCID 46182043Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

Procedure

Prepared from 4-fluoro-2-iso-propoxyaniline and methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate in an analogous fashion to that given in general route 1. Yield (0.25 g, 53%)

Workup

  1. customYield (0.25 g, 53%)

Sources & evidence

ORD record
ord-07f3395e795c4d0d85d7ee056ed2b902
Source dataset
uspto-grants-2013_07
Patent number
US08486953B2

Reaction notes

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