反应详情

温度

60 °C

Methyl 5-methyl-4-(2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylate (0.921 g, 2.30 mmol) was added into a solution of MeOH (8 mL) and 2M aqueous sodium hydroxide (2.0 mL). The reaction was stirred at 60° C. for two hours. The mixture was cooled to ambient temperature and acidified with concentrated hydrochloric acid. On addition of DCM a precipitate formed which was collected and washed with water. The product was purified by reverse phase preparative HPLC to yield off-white solid which was used in the next step without further purification.

1. temperatureThe mixture was cooled to ambient temperature
2. customformed which
3. customwas collected
4. washwashed with water
5. customThe product was purified by reverse phase preparative HPLC
6. customto yield off-white solid which
7. customwas used in the next step without further purification