Ammonia → HCID 46182257, compound

HRID 450581Notes

Reaction equation

HRID 450581 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([O:21]C)=O)[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:3]=1.[NH3:30]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:30])=[O:21])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 46182255HCID 46182255, compound

Product 1

HCID 46182257HCID 46182257, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

A suspension of methyl 4-(4-fluoro-2-(piperidin-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (0.1 g, 0.2 mmol) in 7N ammonia in MeOH (6 mL) was heated in a sealed tube at 120° C. for 18 hours. After cooling to ambient temperature the precipitated solid was collected by filtration, washed with cold MeOH and dried under vacuum to give beige solid (0.035 g, 36%).

Workup

  1. temperatureAfter cooling to ambient temperature the precipitated solid
  2. filtrationwas collected by filtration
  3. washwashed with cold MeOH
  4. customdried under vacuum

Sources & evidence

ORD record
ord-562960ed16a4416eb54c41cf59f8572e
Source dataset
uspto-grants-2013_07
Patent number
US08486953B2

Reaction notes

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