Ammonia → HCID 46182257, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 4-(4-fluoro-2-(piperidin-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (0.1 g, 0.2 mmol) in 7N ammonia in MeOH (6 mL) was heated in a sealed tube at 120° C. for 18 hours. After cooling to ambient temperature the precipitated solid was collected by filtration, washed with cold MeOH and dried under vacuum to give beige solid (0.035 g, 36%).

Provenance & Evidence