反应详情

To N-(3-(dimethylamino)propyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-sulfonamide (0.6 g, 1.8 mmol) was added phosphorus oxychloride (5.0 mL, 36 mmol) and the suspension heated at reflux for 1.5 hours. The reaction was cooled to ambient temperature and the excess phosphorus oxychloride removed under vacuum. The residue was co-evaporated several times with chloroform. Drying under vacuum gave a hydroscopic cream solid that was used without further purification (0.65 g, 92%).

1. temperaturethe suspension heated
2. temperatureat reflux for 1.5 hours
3. customthe excess phosphorus oxychloride removed under vacuum
4. customDrying under vacuum
5. customgave a hydroscopic cream solid that
6. customwas used without further purification (0.65 g, 92%)