Ammonia → HCID 44544870, compound

HRID 450676Notes

Reaction equation

HRID 450676 reaction equation
[CH3:1][C:2]1[CH:14]=[C:5]2[N:6]=[CH:7][C:8]([C:11]([OH:13])=O)=[C:9]([CH3:10])[N:4]2[N:3]=1.O[N:16]=[C:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=1.N>>[CH3:1][C:2]1[CH:14]=[C:5]2[N:6]=[CH:7][C:8]([C:11]3[O:13][N:24]=[C:17]([C:18]4[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=4)[N:16]=3)=[C:9]([CH3:10])[N:4]2[N:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 27363032,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Product 1

HCID 44544870HCID 44544870, compound

Procedure

The title compound was prepared according Method C using 2,7-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (Maybridge) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ2.52 (s, 3 H), 3.27 (s, 3 H), 6.77 (s, 1 H), 7.67 (ddd, J=8.0, 4.9, 0.7 Hz, 1 H), 8.48 (dt, J=8.6, 1.9 Hz, 1 H), 8.84 (dd, J=4.7, 1.7 Hz, 1 H), 9.06 (s, 1 H), 9.30 (dd, J=2.2, 0.8 Hz, 1 H), 9.30 (d, J=1.4 Hz, 1 H) ppm; MS (DCI/NH3) m/z 293 (M+H)+.

Sources & evidence

ORD record
ord-dae4b6fbcbd0466596599071aa1dfd0b
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Reaction notes

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