Morpholine → HCID 58707352, compound

HRID 450850Notes

Reaction equation

HRID 450850 reaction equation
F[C:2]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:3]=1[C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:9]=2[CH:10]=1)=[O:5].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[F:21][C:18]1[CH:19]=[CH:20][C:2]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[C:3]([CH:17]=1)[C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:9]=2[CH:10]=1)=[O:5]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 58707373HCID 58707373, compound

Product 1

HCID 58707352HCID 58707352, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2-(2,5-difluorobenzoyl)-5-methoxybenzofuran (100 mg, 0.28 mmol) and morpholine (100 mg, 1.12 mmol) in toluene (10 ml) is heated at reflux for 24 hours. Evaporation and chromatography on silicagel gives the title compound, m.p. 85-88° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 24 hours
  3. customEvaporation and chromatography on silicagel

Sources & evidence

ORD record
ord-9601fd20bbf544c7aeb7fd61b000bc9e
Source dataset
uspto-grants-2013_07
Patent number
US08486996B2

Reaction notes

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