反应详情

A mixture of cyanothioacetamide (2.0 g, 20 mmol), the sodium salt of ethyl-3-oxo-butenol (2.44 g, 20 mmol) and piperidine acetate (1.9 ml) in water (20 ml) is heated at reflux before adding acetic acid (3 ml). The resulting precipitate is filtered and washed with water. The crude product is dissolved by heating in methanol. Filtering and evaporation of the solvent under reduced pressure yields 5,6-dimethyl-2-mercapto-nicotine nitrile.

1. temperatureat reflux
2. filtrationThe resulting precipitate is filtered
3. washwashed with water
4. dissolutionThe crude product is dissolved
5. temperatureby heating in methanol
6. filtrationFiltering
7. customevaporation of the solvent under reduced pressure