3-Fluorobenzyl bromide → HCID 68800092, compound

HRID 450902Notes

Reaction equation

HRID 450902 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([O:16][CH3:17])[C:12]=1[CH:13]([CH3:15])[CH3:14])[C:6]([O:8]C)=O.[F:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=1)[CH2:22]Br>>[F:18][C:19]1[CH:20]=[C:21]([CH2:22][C:6]([C:5]2[CH:10]=[C:11]([O:16][CH3:17])[C:12]([CH:13]([CH3:15])[CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)([OH:8])[CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[C:19]([F:18])[CH:20]=2)[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 24798870344396-17-4

Product 1

HCID 68800092HCID 68800092, compoundYield 70%

Procedure

This material was prepared in 70% yield from the methyl 3,5-dimethoxy-4-i-propylbenzoate and 3-fluorobenzyl bromide using the same method as described in example 1(b). 1HNMR (CDCl3, ppm): δ 1.29 (d, J=7.1 Hz, 6H), 1.85 (s, 1H), 3.07 (d, J=13.3 Hz, 2H), 3.29 (d, J=13.3 Hz, 2H), 3.56 (qint, J=7.1 Hz, 1H), 3.72 (s, 6H), 6.42 (s, 2H), 6.7-7.2 (m, 8H).

Sources & evidence

ORD record
ord-c21b46e650c04a9292918b9547a9e501
Source dataset
uspto-grants-2013_07
Patent number
US08487009B2

Reaction notes

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