Methyl iodide → 2-Chloro-6-fluoroanisole

Methyl iodide (850 μl, 13.646 mmol) and potassium carbonate (943 mg, 6.824 mmol) were added to 2-chloro-6-fluorophenol (1.0 g, 6.824 mmol) in tetrahydrofuran (10 ml) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was partitioned between diethyl ether (50 ml) and water (50 ml). The organic phase was extracted and further washed with water (2×20 ml) then dried over sodium sulphate and concentrated in vacuo to afford the title compound as a colourless liquid in 94% yield, 1.03 g.

1. customThe reaction mixture was partitioned between diethyl ether (50 ml) and water (50 ml)
2. extractionThe organic phase was extracted
3. washfurther washed with water (2×20 ml)
4. dry with materialthen dried over sodium sulphate
5. concentrationconcentrated in vacuo

ORD 기록

ord-13292b00469244f398ac863ec5476167

출처 데이터셋

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08486992B2