Methylamine → HCID 58075640, compound

HRID 451118Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:11][O:10][CH2:9][CH:8]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[C:6]=2[N:7]=1.[CH3:23][NH2:24]>>[Cl:1][C:2]1[N:3]=[C:4]([NH:24][CH3:23])[C:5]2[CH2:11][O:10][CH2:9][CH:8]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[C:6]=2[N:7]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 58075462HCID 58075462, compound

Product 1

HCID 58075640HCID 58075640, compound

Procedure

2,4-dichloro-8-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (Preparation Z) was reacted as described in Preparation Xa with methanamine to give 2-chloro-N-methyl-8-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine (Preparation Zb). LC-MS (M+H)+=344.1.

Sources & evidence

ORD record: ord-06a48a3f334a460f94f44286598c2ced
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08486952B2

Reaction notes

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