関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 生成物 | Diethyl {[(1-ethyl-1H-pyrazol-5-yl)amino]methylene}malonate | HCID 12845080 | 87.1% |
反応手順
To 2-ethyl-2H-pyrazol-3-ylamine (5.6 g, 0.050 mol) was added 2-ethoxymethylene-malonic acid diethyl ester (10.1 mL, 0.050 mol) and the mixture was heated at 120° C. for 4 hours. After cooling down to RT, the crude mixture was purified by column chromatography (SiO2, EtOAc/Heptane 1/1) to give 12.25 g (86%) of the title compound as a yellow oil. ES-MS m/e: 282.4 (M+H−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08487102B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-ff4f15ee3b7049fc880af5964c8912b3 |
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| 出典メモ | uspto-grants-2013_07 |
|---|
