HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 451213Generated: October 29, 2026
Diethyl (ethoxymethylene)malonate → 2-[(2-Benzyl-2H-pyrazol-3-ylamino)-methylene]-malonic acid diethyl ester
https://huagongshe.com/reaction/451213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 1-Benzyl-1H-pyrazol-5-amine | HCID 77061 | — |
| Product | 2-[(2-Benzyl-2H-pyrazol-3-ylamino)-methylene]-malonic acid diethyl ester | HCID 12845079 | 75% |
Reaction Steps
To 2-benzyl-2H-pyrazol-3-ylamine (5.0 g, 0.0289 mol) was added 2-ethoxymethylene-malonic acid diethyl ester (5.78 mL, 0.0289 mol) and the mixture was heated at 120° C. for 4 hours. After cooling down to RT, the crude mixture was purified by column chromatography (SiO2, EtOAc/Heptane 1/1) to give 7.44 g (75%) of the title compound as a light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08487102B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-59b2cae7cdbc4f328c80254e73adc907 |
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| Source note | uspto-grants-2013_07 |
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