HCID 86699449, compound → HCID 66777897, compound

HRID 451318Notes

Reaction equation

HRID 451318 reaction equation
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][C@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)=[O:19])C1C=CC=CC=1>[Pd].CO>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][C@H:21]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22]1)=[O:19]

Participants

4

Reactant 1

HCID 86699449HCID 86699449, compound

Product 1

HCID 66777897HCID 66777897, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon (335 mg; 10% Pd/C) was added to a solution of the product of Step 1 (1.4 g, 3.15 mmol) in methanol (30 mL) and the resulting mixture was stirred under hydrogen (balloon) for 1 hour. LC-MS analysis showed the reaction was complete. The reaction mixture was filtered and the filtrate was concentrated under vacuum to afford the title compound as an oil which was used without purification in the next step.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-fff6d42b01894414944c261a39c6a225
Source dataset
uspto-grants-2013_07
Patent number
US08487093B2

Reaction notes

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